CD33 is the target of gemtuzumab ozogamicin (trade name: Mylotarg®; Pfizer/Wyeth-Ayerst Laboratories), an antibody-drug conjugate (ADC) for the treatment of patients with acute myeloid leukemia. The drug is a recombinant, humanized anti-CD33 monoclonal antibody (IgG4 κ antibody hP67.
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CD33 is a cell surface antigen that is present in more than 80% of patients with AML but is absent from pluripotent hematopoietic stem cells. GO is a humanized ...
Dec 12, 2018 · CD33 is an inhibitory receptor. It can be constitutively activated by sialic acid-containing glycoproteins and glycolipids. The activated CD33 ...
CD33
Protein
CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.
It binds sialic acids, therefore is a member of the SIGLEC family of... Wikipedia
Molecular function: protein binding; carbohydrate binding; signaling receptor activity; protein phosphatase binding; sialic acid binding
Targeting CD33 for acute myeloid leukemia therapy - BMC Cancer
bmccancer.biomedcentral.com › articles
Jan 3, 2022 · The aim of this study was to analyze the level of CD33 expression in patients with newly diagnosed AML and determine its correlation with ...
CD33 is a member of the sialic acid–binding Ig-like lectins (siglecs), which generally mediate cell–cell interactions and cell signaling.
Jun 13, 2014 · High CD33 expression on AML blasts was already reported three decades ago. CD33 was detected on blasts of 85–90% of patients presenting with AML ...
Jun 28, 2021 · Roughly 85–90% of adult and pediatric acute myeloid leukemia (AML) are CD33-positive. Gemtuzumab ozogamicin (GO), a humanized murine IgG4 anti- ...
CD33 (CD33 Molecule) is a Protein Coding gene. Diseases associated with CD33 include Childhood T-Cell Acute Lymphoblastic Leukemia and Acute Promyelocytic ...
Mar 23, 2024 · A polymorphism near CD33 is a genetic risk factor for Alzheimer's disease. The allele protecting from AD increases a CD33 isoform lacking exon 2 ...
Jan 19, 2016 · CD33 is variably expressed on acute myeloid leukemia (AML) blasts and is targeted by gemtuzumab ozogamicin (GO).
