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What is the DDR1 gene?
What is the function of DDR1?
It interacts with the receptor tyrosine kinase DDR1 and is frequently lost from metastatic mammary tumors. Here, using genetic tracing, we demonstrate Syk ...
Jun 26, 2014 · The discoidin domain receptors (DDRs), DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding ...
Missing: Sebastian | Show results with:Sebastian
Nov 19, 2019 · Abstract. The collagen receptor DDR1 is a receptor tyrosine kinase that promotes progression of a wide range of human disorders. Little is known ...
Jul 30, 2013 · In this paper we implemented a focused medicinal chemistry library approach to discover two new potent DDR1 kinase inhibitors. DDR1-IN-1 is a ...
Discoidin domain receptor 1 (DDR1) is a tyrosine kinase receptor that is activated by fibrillar collagens. Here, we review the expression and role of DDR1 in ...
Missing: Sebastian | Show results with:Sebastian
Sep 12, 2023 · Discoidin domain receptor 1 (DDR1) is an important signal transducer that mediates crosstalk between cancer cells and their surrounding stroma.
Jun 7, 2017 · Ligand binding induces DDR1 kinase activity through recruitment of DDR1 receptors into signalling clusters in which phosphorylation occurs ...
Targeting the receptor for collagens DDR1 by nilotinib inhibits mCRC cells properties and paves the way to a new therapeutic strategy for mCRC. •. DDR1 tyrosine ...
Oct 27, 2020 · Silencing of DDR1 before tumor inoculation reduced hepatic C26 metastasis in mice. Silenced livers bore less tumor foci than controls.