The SURF1 gene provides instructions for making a protein that is important in oxidative phosphorylation, the process by which the energy from food is ...
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Apr 11, 2024 · This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c ...
Dec 5, 2021 · Mutations in SURF1 can cause Leigh syndrome (LS), a subacute neurodegenerative encephalopathy, characterized by early onset (infancy), grave ...
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex.
Surfeit locus protein 1 (SURF1) is a protein that in humans is encoded by the SURF1 gene. The protein encoded by SURF1 is a component of the mitochondrial ...
Jul 5, 2013 · SURF1 deficiency, a monogenic mitochondrial disorder, is the most frequent cause of cytochrome c oxidase (COX) deficient Leigh syndrome (LS) ...
The SURF1 gene encodes an assembly factor of mitochondrial complex IV (COX), the terminal component of the mitochondrial respiratory chain (summary by ...
SURF1 represents a major gene for LS associated with COX deficiency. Several other COX assembly genes have been shown to be responsible for COX deficiencies, in ...
Dec 1, 1998 · SURF1 was evaluated as a candidate gene in LS patients with COX deficiency because it mapped to the non-excluded region of chromosome 9 and ...