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Okazaki fragments are short sequences of DNA nucleotides which are synthesized discontinuously and later linked together by the enzyme DNA ligase to create ...
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Thus, this Okazaki fragment duplex assumes a conformation in solution that is a chimeric mixture of hybrid-form (H-form) and B-form structures and the overall ...
Feb 15, 2019 · In a 1968 paper in PNAS, Reiji and Tsuneko Okazaki and colleagues (1) proposed that the lagging strand is replicated discontinuously in the form ...
Jul 22, 2022 · Unligated Okazaki fragments are a major source of DNA single-strand breaks in eukaryotic cells. Cells activate DNA damage response checkpoints ...
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This enzyme recognizes the trinucleotide sequence d(CTG) within the DNA template and uses two of those nucleotides to direct the synthesis of the first ...
Our data support a model for Okazaki fragment processing where the strand displacement activity of DNA polymerase δ is modulated by the concerted action of PCNA ...
Okazaki fragments are small sections of DNA that are formed during discontinuous synthesis of the lagging strand during DNA replication.
Nov 15, 2022 · The final steps of lagging strand synthesis induce maturation of Okazaki fragments via removal of the RNA primers and ligation.