TRIM8 is a novel gene responsible for epileptic encephalopathy, possibly associated with nephrotic syndrome. In the current study the authors identified TRIM8, ...
This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an ...
Sep 2, 2020 · TRIM8 has been identified as a novel gene responsible for early-onset epileptic encephalopathy (EOEE) and epileptic encephalopathy (EE).
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Mar 5, 2021 · Mutations in the TRIM8 gene have been associated with several rare disorders including developmental delay and intellectual disability with ...
Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component ...
Sep 8, 2021 · TRIM8 in Ewing sarcoma ... EWS/FLI is a chimeric fusion oncogene that drives tumour formation and progression in Ewing sarcoma. Using a CRISPR– ...
The TRIM8 gene encodes a 551-amino acid tripartite E3 ubiquitin ligase that plays a role in the regulation of several signaling pathways (summary by ...
Dec 20, 2021 · Heterozygous truncating variants in the Tripartite motif containing 8 (TRIM8) gene have been reported to cause epileptic encephalopathy, ...
May 30, 2022 · Background: TRIM8 gene mutations have been reported as the genetic basis of autosomal dominant (AD) neuro-renal syndrome in children, ...
A TRIM8 mutant inhibited NF-κB activation mediated by overexpression of TAK1 as well as its upstream components but not downstream p65. Stimulation of cells ...
